Taken from WWW.pubmed.gov (testosterone studies)

Endocrinol Metab Clin North Am. 2007 Jun;36(2):365-77.

Why men's hearts break: cardiovascular effects of sex steroids.

Choi BG, McLaughlin MA.

The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.

Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.

PMID: 17543724 [PubMed - in process]

Dr. Gordon: The most likely reason that estrogen replacement is not cardioprotective in women is that the administration of estrogen leads to a precipitous drop in testosterone levels. It might well be the case that ALL adverse effects of estrogen replacement are due to the virtual disappearance of testosterone.

CAD Studies

Medical Studies