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Taken from WWW.pubmed.gov (testosterone studies)
Circulation. 2006 Oct 24;114(17):1829-37. Epub 2006 Oct 9.
Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival.
Jankowska EA,
Biel B,
Majda J,
Szklarska A,
Lopuszanska M,
Medras M,
Anker SD,
Banasiak W,
Poole-Wilson PA,
Cardiology Department, Military Hospital, ul. Weigla 5, 50-981 Wroclaw, Poland. Ewa.Jankowska@antro.pan.wroc.pl
BACKGROUND: The age-related decline of circulating anabolic hormones in men is associated with increased
morbidity and mortality. We studied the prevalence and prognostic consequences of deficiencies in
circulating total testosterone (TT) and free testosterone, dehydroepiandrosterone sulfate (DHEAS), and
insulin-like growth factor-1 (IGF-1) in men with chronic heart failure (CHF).
METHODS AND RESULTS: Serum levels of TT, DHEAS, and IGF-1 were measured with immunoassays in 208 men with CHF
(median age 63 years; median left ventricular ejection fraction 33%; New York Heart Association class I/II/III/IV,
19/102/70/17) and in 366 healthy men. Serum levels of free testosterone were estimated (eFT) from levels of TT and sex
hormone binding globulin. Deficiencies in DHEAS, TT, eFT, and IGF-1, defined as serum levels at or below
the 10th percentile of healthy peers, were seen across all age categories in men with CHF. DHEAS, TT, and
eFT were inversely related to New York Heart Association class irrespective of cause (all P<0.01). DHEAS
correlated positively with left ventricular ejection fraction and inversely with N-terminal pro-brain
natriuretic peptide (both P<0.01). Circulating TT, eFT, DHEAS, and IGF-1 levels were prognostic markers
in multivariable models when adjusted for established prognostic factors (all P<0.05). Men with CHF and
normal levels of all anabolic hormones had the best 3-year survival rate (83%, 95% CI 67% to 98%) compared
with those with deficiencies in 1 (74% survival rate, 95% CI 65% to 84%), 2 (55% survival rate, 95% CI 45%
to 66%), or all 3 (27% survival rate, 95% CI 5% to 49%) anabolic endocrine axes (P<0.0001).
CONCLUSIONS:
In male CHF patients, anabolic hormone depletion is common, and a deficiency of each anabolic hormone is
an independent marker of poor prognosis. Deficiency of >1 anabolic hormone identifies groups with a higher
mortality.
PMID: 17030678 [PubMed - indexed for MEDLINE]
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