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Taken from WWW.pubmed.gov (testosterone studies)
Curr Alzheimer Res. 2007 Feb;4(1):33-45.
Testosterone and cognition in normal aging and Alzheimer's disease: an update.
Driscoll I,
Resnick SM.
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD, USA.
driscolli@mail.nih.gov.
There is evidence to suggest that testosterone loss constitutes a risk for cognitive decline and possibly
dementia, and that elderly men might benefit from exogenous supplementation of testosterone. Studies in
non-human animals repeatedly report neuroexcitatory and neuroprotective properties of testosterone and
enhanced memory performance after acute or chronic treatment. Positive effects of testosterone
supplementation in older men have been reported in several, but not all, studies and require replication in
larger randomized clinical trials before recommendations for clinical practice can be made. The current
review summarizes recent studies on the neurobiological connection between testosterone and cognitive
function in humans and non-human animals. When appropriate, we use the hippocampus as a model structure
given it's involvement in sexually dymorphic spatial ability and sensitivity to both androgens and aging.
In addition, a number of potential explanations of the discrepancy between data obtained in humans and
non-human animals are discussed.
PMID: 17316164 [PubMed - in process]
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