Testosterone Deficiency The Hidden Disease
by E. Barry Gordon, M.D.
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Taken from WWW.pubmed.gov (testosterone studies)
Curr Urol Rep. 2007 Nov;8(6):467-71.
Testosterone, diabetes mellitus, and the metabolic syndrome
Spark RF.
Metabolic syndrome is characterized by insulin insensitivity, central obesity dyslipidemia, and hypertension.
It is recognized as a risk factor for cardiovascular disease in men; by the time metabolic syndrome is diagnosed,
however, most men already have entrenched cardiovascular disease. A reliable early warning sign is needed to alert
physicians to those at risk for metabolic syndrome and cardiovascular disease. Low serum testosterone level has
emerged as a reliable prognosticator of metabolic syndrome in men whose testosterone deficiency is genetic
(Klinefelter syndrome), iatrogenic following surgery for testicular cancer, pharmacologically induced by
gonadotropin-releasing hormone during prostate cancer treatment, or a natural consequence of aging. One third of
men with type 2 diabetes mellitus are now recognized as testosterone deficient. Emerging evidence suggests
that testosterone therapy may be able to reverse some aspects of metabolic syndrome.
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